| 产品详情 |
| Edit |   |
|---|
| Product Name | NVP-BHG712 |
|---|
| Description | Purity >98%. The EphB4 receptor tyrosine kinase (cloned from erythropoietin-producing hepatocellular carcinoma) and its ligand ephrinB2 play an important role in embryonic vessel development and vascular remodeling. Signaling from this pair is also involved in tumor angiogenesis. NVP-BHG712 is an orally bioavailable inhibitor of EphB4 kinase autophosphorylation (ED50 = 25 nM). It is selective for EphB4, demonstrating an ED50 value of 4.2 µM at the related VEGFR2 receptor and ED50 values >10 µM against a panel of 40 additional kinases. At 3-30 mg/kg, NVP-BHG712 dose dependently inhibits VEGF-directed vessel formation in an in vivo mouse model of angiogenesis. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]-benzamide |
|---|
| Gene, Accession, CAS # | CAS: 940310-85-0 |
|---|
| Catalog # | LS-H9114 |
|---|
| Price | |
|---|
| Order / More Info | NVP-BHG712 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|