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| Product Name | NVP-BKM120 |
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| Description | Purity >95%. Phosphatidylinositol 3-kinases (PI3K) belong to a family of lipid kinases that is involved in many types of cancer. NVP-BKM120 is an orally bioavailable inhibitor of class I PI3K isoforms, potently blocking, in vitro, both p110Alpha (IC50 = 52 nM) and p110Beta (IC50 = 166 nM). It much less effectively inhibits the class III PI3K Vps34 and mammalian target of rapamycin and has no effect on PI4KBeta and several other kinases. NVP-BKM120 prevents the growth of assorted cancer cell lines when used at 5 µM and inhibits tumor growth in vivo . It can be particularly effective against certain types of cancer when combined with other modulators. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine, Buparlisib |
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| Gene, Accession, CAS # | CAS: 944396-07-0 |
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| Catalog # | LS-H9115 |
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| Order / More Info | NVP-BKM120 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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