| 产品详情 |
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| Product Name | Ubiquitin-Conjugating Enzyme E2B (UBE2B) protein (His tag) |
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| Description | Homolog of Rad6 B (HR6B), also known as ubiquitin-conjugating Enzyme E2B (UBE2B), is a ubiquitously expressed member of the ubiquitin-conjugating (E2) enzyme family. It has a predicted molecular weight of 17 kDa. The human enzyme shares 100% amino acid sequence identity with the mouse and rat orthologs. HR6B/UBE2B localizes to the nucleus and cytoplasm and is highly expressed in the brain, heart and testis. HR6B/UBE2B has an E2 catalytic core domain with an active site cysteine residue that is required for the formation of a thioester bond with ubiquitin. PCNA is mono-ubiquitinated by HR6B/UBE2B via the RAD18 ubiquitin ligase (E3). HR6B/UBE2B also functions with the UBR2 E3 to ubiquitinate Histone H2A. HR6B/UBE2B plays important roles during spermatogenesis and is required for fertility in male mice. Pathologically, HR6B/UBE2B is overexpressed in mouse and human breast cancer cell lines and tumors and has been reported to provide resistance to chemotherapy drugs. |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | fc79h10|wu:fc79h10|zgc:100921|e2-17kda|hhr6b|hr6b|rad6b|ubc2|E2-17kDa|HHR6B|HR6B|RAD6B|UBC2|2610301N02Rik|E2-14k|Rad6b|mHR6B |
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| Gene, Accession, CAS # | Gene ID: 7320 |
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| Catalog # | ABIN2745704 |
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| Order / More Info | Ubiquitin-Conjugating Enzyme E2B (UBE2B) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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