| 产品详情 |
| Edit |   |
|---|
| Product Name | Ubiquitin-Conjugating Enzyme E2B (UBE2B) protein (His tag) |
|---|
| Description | Homolog of Rad6 B (HR6B), also known as ubiquitin-conjugating Enzyme E2B (UBE2B), is a ubiquitously expressed member of the ubiquitin-conjugating (E2) enzyme family. It has a predicted molecular weight of 17 kDa. The human enzyme shares 100% amino acid sequence identity with the mouse and rat orthologs. HR6B/UBE2B localizes to the nucleus and cytoplasm and is highly expressed in the brain, heart and testis. HR6B/UBE2B has an E2 catalytic core domain with an active site cysteine residue that is required for the formation of a thioester bond with ubiquitin. PCNA is mono-ubiquitinated by HR6B/UBE2B via the RAD18 ubiquitin ligase (E3). HR6B/UBE2B also functions with the UBR2 E3 to ubiquitinate Histone H2A. HR6B/UBE2B plays important roles during spermatogenesis and is required for fertility in male mice. Pathologically, HR6B/UBE2B is overexpressed in mouse and human breast cancer cell lines and tumors and has been reported to provide resistance to chemotherapy drugs. |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | SDS-PAGE (SDS) |
|---|
| Other Names | fc79h10|wu:fc79h10|zgc:100921|e2-17kda|hhr6b|hr6b|rad6b|ubc2|E2-17kDa|HHR6B|HR6B|RAD6B|UBC2|2610301N02Rik|E2-14k|Rad6b|mHR6B |
|---|
| Gene, Accession, CAS # | Gene ID: 7320 |
|---|
| Catalog # | ABIN2745705 |
|---|
| Price | |
|---|
| Order / More Info | Ubiquitin-Conjugating Enzyme E2B (UBE2B) protein (His tag) from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|