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| Product Name | Ubiquitin-Conjugating Enzyme E2C (UBE2C) protein |
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| Description | Ubiquitin-conjugating Enzyme H10 (UbcH10), also known as ubiquitin-conjugating enzyme E2C (UBE2C), is a 179 amino acid (aa) member of the yeast Ubc4/5 family of ubiquitin-conjugating (E2) enzymes and has a predicted molecular weight of 20 kDa. Human UbcH10/UBE2C shares 96% aa sequence identity with mouse and rat UBE2C. UbcH10/UBE2C is an essential mediator of mitotic destruction events and cell cycle progression. UbcH10/UBE2C recognizes TEK sequences in target proteins such as Cyclins A and B, mediates Lys11-linked ubiquitination and promotes target protein degradation in conjunction with APC/C, a ubiquitin ligase (E3). The catalytic activity of UbcH10/UBE2C is regulated by a conserved N-terminal extension, which mediates E2-E3 interaction. UbcH10/UBE2C is overexpressed in a variety of human cancers and alternate splice isoforms may contribute to uncontrolled cell proliferation and tumor progression. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | LOC458287|UBCH10|dJ447F3.2|1110015A16Rik|D2Ertd695e|im:7137135|zgc:123190 |
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| Gene, Accession, CAS # | Gene ID: 11065 |
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| Catalog # | ABIN2745884 |
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| Order / More Info | Ubiquitin-Conjugating Enzyme E2C (UBE2C) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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