| 产品详情 |
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| Product Name | AICAR |
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| Description | Purity >98%. AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress. AICAR is a selective activator of AMP-activated protein kinase (AMPK) in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-Alpha/IL-1Beta and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NF-?B and C/EBP pathways. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-amino-1-Beta-D-ribofuranosyl-1H-imidazole-4-carboxamide, NSC 105823, Acadesine, AICA riboside |
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| Gene, Accession, CAS # | CAS: 2627-69-2 |
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| Catalog # | LS-H6459 |
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| Price | |
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| Order / More Info | AICAR from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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