| 产品详情 |
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| Product Name | Beclin 1, Autophagy Related (BECN1) (AA 1-450) protein (His tag) |
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| Description | Beclin-1 (Bcl-2 interacting coiled-coil protein, ATG6) is a multifunctional protein, well-known as a key regulator of autophagy and required for the initiation step in autophagosome formation. It interacts with several cofactors (Atg14L, UVRAG, Bif-1, rubicon, Ambra1, HMGB1, nPIST, VMP1, SLAM, IP3R, PINK and survivin) to regulate the lipid kinase PI3K protein and promote formation of PIK3C3/VPS34-containing complexes. These interactions induce autophagy, which is a process of programmed cell survival increased during periods of cell stress and extinguished during the cell cycle. Furthermore, beclin-1 is implicated in numerous biological processes, including adaptation to stress, development, endocytosis, cytokinesis, immunity, infection, tumorigenesis, aging and cell death. Beclin-1 is tightly regulated by diverse mechanisms, such as epigenetic silencing, microRNA regulation, post-translational modifications and protein-protein interactions. Multiple diseases are associated with deficiency or malfunction of beclin-1, including cancer and neurodegeneration. |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | SDS-PAGE (SDS) |
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| Other Names | beclin-1|atg6|vps30|beclin1|Beclin-1|becn1|zgc:73097|ATG6|VPS30|4921513J16Rik|5430417M23Rik|Atg6 |
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| Gene, Accession, CAS # | Gene ID: 8678 |
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| Catalog # | ABIN2745620 |
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| Order / More Info | Beclin 1, Autophagy Related (BECN1) (AA 1-450) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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