| 产品详情 |
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| Product Name | HG-10-102-01 |
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| Description | Purity >98%. HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM). It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50 s = 3.2, 153, and 95.9 nM, respectively). HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone |
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| Gene, Accession, CAS # | CAS: 1351758-81-0 |
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| Catalog # | LS-H8105 |
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| Price | |
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| Order / More Info | HG-10-102-01 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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