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| Product Name | D-Alpha-Hydroxyglutaric Acid (sodium salt) |
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| Description | Purity >95%. D-Alpha-Hydroxyglutaric Acid (D-2-HG) is an Alpha-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2, causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this Alpha-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an Alpha-hydroxyglutaric acid synthetase. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2R-hydroxy-pentanedioic acid, disodium salt, D-2-HG, D-2-Hydroxyglutaric Acid |
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| Gene, Accession, CAS # | CAS: 103404-90-6 |
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| Catalog # | LS-H7608 |
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| Order / More Info | D-Alpha-Hydroxyglutaric Acid (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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