| 产品详情 |
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| Antigenic Specificity | SPG11 |
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| Clone | 2H25L11 |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 5 µg/mL, Western Blot: 2.5 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SPG11 Antibody (2H25L11), ABfinity™ Rabbit Monoclonal. SPG11 (Spatacsin) plays a role in neurite plasticity by maintaing cytoskelton stability and regulating synaptic vesicle transport. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene. Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism. |
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| Immunogen | n/a |
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| Other Names | KIAA1840 |
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| Gene, Accession # | Entrez: 80208; Uniprot: Q96JI7 |
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| Catalog # | 702776 |
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| Price | |
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| Order / More Info | SPG11 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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