| 产品详情 |
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| Product Name | CH 223191 |
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| Description | Purity >95%. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that up-regulates many xenobiotic metabolizing enzymes, particularly in response to planar aromatic hydrocarbons. CH 223191 is a potent and specific antagonist of AhR that blocks activation by 2,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD, IC50 = 0.03 µM). It prevents the induction of cytochrome P450 1A1 by TCDD in HepG2 cells and in livers of mice. Through its effects on AhR, CH 223191 suppresses Th17 cell differentiation both in vitro and in vivo and alters the expression of homeobox transcription factors necessary for the differentiation of embryonic stem cells to cardiomyocytes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide |
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| Gene, Accession, CAS # | CAS: 301326-22-7 |
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| Catalog # | LS-H7097 |
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| Order / More Info | CH 223191 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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