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| Product Name | CH5424802 |
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| Description | Purity >95%. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. CH5424802 is an ATP-competitive inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50 s = 1.0, 3.5, and 1.6 nM, respectively). It shows more than 500-fold selectivity for ALK over a panel of 24 other kinases. CH5424802 is orally available and inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile, Alectinib, RO5424802 |
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| Gene, Accession, CAS # | CAS: 1256580-46-7 |
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| Catalog # | LS-H7100 |
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| Price | |
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| Order / More Info | CH5424802 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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