| 产品详情 |
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| Product Name | INT-777 |
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| Description | Purity >95%. TGR5 is a transmembrane G protein-coupled receptor that is activated by bile acid. INT-777 is a semisynthetic bile acid that acts as an agonist of TGR5 (EC50 = 0.82 µM). It is active in vivo, stimulating the secretion of glucagon-like peptide 1 (GLP-1) in mice when given orally (30 mg/kg) after a glucose challenge, particularly when given with a dipeptidyl-peptidase-4 inhibitor. INT-777 increases energy expenditure and reduces hepatic steatosis and adiposity in mice subjected to diet-induced obesity. It also stimulates insulin secretion in pancreatic Beta-cells, reduces inflammation and inhibits atherosclerosis in mice, and promotes chloride secretion through cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3a,5Beta,6a,7a,12a,23S)-6-ethyl-3,7,12-trihydroxy-cholane-23-carboxylic acid, 6-EMCA, HY-15677, S-EMCA |
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| Gene, Accession, CAS # | CAS: 1199796-29-6 |
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| Catalog # | LS-H8222 |
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| Price | |
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| Order / More Info | INT-777 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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