| 产品详情 |
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| Product Name | Luffariellolide |
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| Description | Purity >98%. Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 µM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 µM, acts as an agonist for the RA receptors RAR Alpha, Beta, and Gamma but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 µM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-2(5H)-furanone |
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| Gene, Accession, CAS # | CAS: 111149-87-2 |
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| Catalog # | LS-H8534 |
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| Price | |
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| Order / More Info | Luffariellolide from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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