| 产品详情 |
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| Antigenic Specificity | Phospho-Rb (Ser788) |
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| Clone | 6HCLC |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 2 µg/mL, Immunofluorescence: 2 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-Rb (Ser788) Antibody (6HCLC), ABfinity™ Rabbit Oligoclonal. Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethyl |
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| Immunogen | n/a |
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| Other Names | Retinoblastoma 1; p105-Rb; pRb; pp110; Retinoblastoma-associated protein |
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| Gene, Accession # | Entrez: 5925; Uniprot: P06400 |
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| Catalog # | 711143 |
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| Price | |
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| Order / More Info | Phospho-Rb (Ser788) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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