| 产品详情 |
| Edit |   |
|---|
| Product Name | GSK-J4 |
|---|
| Description | Purity >99% by TLC and NMR. GSK-J4 is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNFa release). Cell permeable, ethyl ester of GSK J1. GSK-J4 rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester |
|---|
| Gene, Accession, CAS # | CAS: 1373423-53-0 |
|---|
| Catalog # | LS-H14699 |
|---|
| Price | |
|---|
| Order / More Info | GSK-J4 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|