| 产品详情 |
| Edit |   |
|---|
| Product Name | Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (Active) protein |
|---|
| Description | Stromal-Cell Derived Factor-1 alpha/ CXCL12 (SDF-1a) and SDF-1b, members of the chemokine alpha subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line as cytokines that supported the proliferation of a stromal cell-dependent pre-B-cell line. SDF-1a and SDF-1b cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1a and SDF-1b are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1b and absent from SDF-1a. SDF-1/PBSF is highly conserved between species, with only one amino acid substitution between the mature human and mouse proteins. SDF-1/PBSF acts via the chemokine receptor CXCR4 and has been shown to be a chemoattractant for T-lymphocytes, monocytes, pro- and pre- B cells, but not neutrophils. Mice lacking SDF-1 or CXCR4 have been found to have impaired B-lymphopoiesis, myelopoiesis, vascular development, cardiogenesis and abnormal neuronal cell migration and patterning in the central nervous system.Synonyms: Murine Stromal-Cell Derived Factor-1 alpha |
|---|
| Size | 1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | sdf1a|a-sdf1a|IRH|PBSF|SCYB12|SDF1|TLSF|TPAR1|Pbsf|Scyb12|Sdf1|Tlsf|Tpar1|sdf-1|sdf1|xSDF-1|SDF-1 |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | ABIN2018349 |
|---|
| Price | |
|---|
| Order / More Info | Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (Active) protein from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|