| 产品详情 |
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| Product Name | CID16020046 |
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| Description | Purity >97%. GPR55 is a G protein-coupled receptor (GPCR) that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI). CID16020046 is a GPR55 inverse agonist that antagonizes GPR55 constitutive activity with an IC50 value of 15 µM. It inhibits GPR55-mediated ERK1/2 phosphorylation, LPI-induced Ca2+ signaling (IC50 = 0.21 µM in HEK-GPR55 cells), and GPR55-mediated transcription factor activation. It does not affect ERK1/2 phosphorylation or transcription factor activation in CB receptor expressing cells and demonstrates weak activity against a broad spectrum of other GPCRs, ion channels, kinases, and nuclear receptors. This compound has been shown to block GPR55-mediated endothelial wound healing and reverse LPI-inhibited platelet aggregation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-benzoic acid |
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| Gene, Accession, CAS # | CAS: 834903-43-4 |
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| Catalog # | LS-H116 |
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| Price | |
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| Order / More Info | CID16020046 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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