| 产品详情 |
| Edit |   |
|---|
| Product Name | ELR510444 |
|---|
| Description | Purity >95%. ELR510444 is an inhibitor of tubulin polymerization (IC50 = 10 µM) that binds to tubulin at the colchicine binding site. It induces microtubule depolymerization in A-10 cells (EC50 = 21 nM). ELR510444 inhibits growth in a cancer cell line panel (IC50 s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest. Oral administration of ELR510444 (3-6 mg/kg) reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner. ELR510444 also inhibits hypoxia-inducible factor 1Alpha (HIF-1Alpha) in RCC4 cells in a concentration-dependent manner. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-benzenesulfonamide |
|---|
| Gene, Accession, CAS # | CAS: 1233948-35-0 |
|---|
| Catalog # | LS-H7648 |
|---|
| Price | |
|---|
| Order / More Info | ELR510444 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|