| 产品详情 |
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| Product Name | APY29 |
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| Description | Purity >98% by HPLC. APY29 is a highly potent and selective allosteric modulator of IRE1a. Under endoplasmic reticulum (ER) stress, unfolded proteins accumulate in the ER to activate the ER transmembrane kinase/endoribonuclease (RNase)-IRE1a. IRE1a oligomerizes, autophosphorylates, and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). APY29 Inhibits IRE1a autophosphorylation (IC50 = 280 nM) and activates IRE1aRNase activity. As dysregulation of the UPR has been implicated in a variety of cell degenerative and neoplastic disorders, small molecule modulators of IRE1a should be very useful in understanding UPR's role in pathophysiology and to develop drugs for ER stress-related diseases. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine |
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| Gene, Accession, CAS # | CAS: 1216665-49-4 |
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| Catalog # | LS-H3158 |
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| Price | |
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| Order / More Info | APY29 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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