| 产品详情 |
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| Product Name | IM-12 |
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| Description | Purity >98%. Glycogen synthase kinase 3Beta (GSK3Beta) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate Beta-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to Beta-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases Beta-catenin levels by inhibiting GSK3Beta (IC50 = 53 nM). It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain. IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, GSK3-Beta Inhibitor XIX |
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| Gene, Accession, CAS # | CAS: 1129669-05-1 |
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| Catalog # | LS-H8186 |
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| Price | |
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| Order / More Info | IM-12 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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