| 产品详情 |
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| Product Name | RP 001 (hydrochloride) |
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| Description | Purity >98%. RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P1 ) agonist (EC50 = 9 pM). It is competitive with W146 , a selective S1P1 antagonist, and induces internalization and polyubiquitination of S1P1 in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg). It reduces S1P1 -EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice but has no effect in vivo . RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-Beta-alanine, monohydrochloride |
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| Gene, Accession, CAS # | CAS: 1781880-34-9 |
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| Catalog # | LS-H9764 |
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| Order / More Info | RP 001 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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