| 产品详情 |
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| Product Name | Farnesyl Thiosalicylic Acid |
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| Description | Purity >96%. Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) is an inhibitor of Ras-mediated signaling that functions by dislodging Ras from the cell membrane thereby rendering it susceptible to proteolytic degradation. FTS inhibits the growth of human Ha-ras-transformed Rat1 fibroblasts with an IC50 value of 7.5 µM. It does not inhibit Ras farnesylation in vitro and although FTS does inhibit prenylated protein methyltransferase (PPMTase) in cell-free systems with a Ki value of 2.6 µM, it is relatively ineffective at inhibiting methylation in whole cells. Treatment of chow-fed ApoE-deficient mice with 5 mg/kg FTS three times per week for six weeks reduces early atherosclerotic lesion development by 52% compared to controls. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-benzoic acid, FTS, Salirasib |
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| Gene, Accession, CAS # | CAS: 162520-00-5 |
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| Catalog # | LS-H7756 |
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| Price | |
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| Order / More Info | Farnesyl Thiosalicylic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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