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| Product Name | SLIGRL-NH2 |
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| Description | Purity >98%. Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand. The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2). SLIGRL-NH2 is a recombinant peptide that activates PAR2 (EC50 = ~5 µM), without requiring receptor cleavage. This peptide does not activate PAR1. Through its effects on PAR2, SLIGRL-NH2 stimulates gastric and intestinal smooth muscle contraction and induces thermal hyperalgesia in mice. SLIGRL-NH2 is used to explore signaling through PAR2 in cells and in animals. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | L-seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-Leucinamide |
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| Gene, Accession, CAS # | CAS: 171436-38-7 |
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| Catalog # | LS-H9944 |
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| Order / More Info | SLIGRL-NH2 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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