| 产品详情 |
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| Product Name | UNC0321 (trifluoroacetate salt) |
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| Description | Purity >95%. The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0321 is a potent and selective G9a HMTase inhibitor, exhibiting a Ki value of 63 pM. UNC0321 inhibits G9a with assay-dependent IC50 values of 6-9 nM and GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 15-23 nM. It is more than 40,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and JMJD2E. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, tri(trifluoroacetate) salt |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H10366 |
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| Price | |
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| Order / More Info | UNC0321 (trifluoroacetate salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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