| 产品详情 |
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| Product Name | Wortmannin |
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| Description | Purity >98%. By phosphorylating phosphatidylinositol, phosphoinositide 3-kinases (PI3K), activates diverse cellular functions, including cell growth, differentiation, survival, and motility. Wortmannin is a potent, cell-permeable, and irreversible inhibitor of PI3K enzymes (IC50 = 1-10 nM). However, the class II PI3Ks from Drosophila, murine, and human differ in sensitivity to wortmannin (IC50 = 5, 50, 450 nM, respectively). Wortmannin also inhibits polo-like kinase 1 (IC50 = 24 nM)2 and polo-like kinase 3 (IC50 = 49 nM)3, as well as mTOR, DNA-PK, PI4K, MLCK, and p38 MAPK at 50 to 100 fold higher concentrations than that needed for PI3K inhibition. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione, KY 12420 |
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| Gene, Accession, CAS # | CAS: 19545-26-7 |
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| Catalog # | LS-H10496 |
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| Order / More Info | Wortmannin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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