| 产品详情 |
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| Product Name | SirReal2 |
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| Description | Purity >98%. Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and Alpha-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing Alpha-tubulin acetylation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-acetamide |
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| Gene, Accession, CAS # | CAS: 709002-46-0 |
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| Catalog # | LS-H9932 |
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| Price | |
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| Order / More Info | SirReal2 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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