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| Antigenic Specificity | Cox-2, C-terminus |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | 55 mg/mL |
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| Applications | ELISA, Immunohistochemistry, Western Blot. Cox-2 (Cyclooxygenase-2) is an inducible enzyme that is normally absent from cells, however, in response to growth factors, tumor promoters and some cytokines, it undergoes a rapid and transient expression. This antiserum against Human Cox-2 and has been tested for use in immunoblotting and ELISA. The antibody recognizes Cox-2 at 70kDa in Sf9 cell lines transfected with Cox-2 as well as in WISH cells induced with IL-1b. Reactivity in other immunoassays is unknown. |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This antiserum is directed against human Cox-2 and is useful in determining its presence in western blotting and ELISA experiments. The antibody does not cross react with Cox-1. Cox-2 is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, Cox-2 is therefore of interest in studying immune response regulation. This antibody can detect Cox-2 in human, mouse and rat. Reactivity of this antibody with Cox-2 from other species is unknown. |
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| Immunogen | This whole rabbit serum was prepared by repeated immunizations with a fusion protein corresponding to the carboxy-terminus of human Cox-2. |
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| Other Names | rabbit anti-COX2 antibody, Prostaglandin G/H synthase 2 antibody, Cyclooxygenase-2 antibody, Prostaglandin-endoperoxide synthase 2 antibody, Prostaglandin H2 synthase 2 antibody, PGH synthase 2 antibody, PGHS-2 antibody |
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| Gene, Accession # | PTGS2, COX2, Gene ID: 5743, NCBI: P35354.2, UniProt: P35354 |
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| Catalog # | 100-401-226 |
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| Price | |
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| Order / More Info | Cox-2, C-terminus Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | Tai, H. et. al., (2000) Induction of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells. Biochem Biophys Res Commun. Sep 16;276(1):77-81.Guan, Z. et al. (1998) Interleukin-1-induced Cyclooxygenase-2 Expression Requires Activation of Both c-Jun NH2-terminal Kinase and p38 MAPK Signal Pathways in Rat Renal Mesangial Cells. J.Biol Chem, 273(44): 28670-28676. |
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