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| Product Name | Octyl-Alpha-hydroxyglutarate |
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| Description | Purity >95%. Alpha-Hydroxyglutaric acid (2-HG) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder. Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than Alpha-ketoglutarate. 2-HG is structurally similar to Alpha-ketoglutarate and competitively inhibits Alpha-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases. Octyl-Alpha-hydroxyglutarate is a cell-permeable derivative of 2-HG. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-hydroxy-5-(octyloxy)-5-oxopentanoic acid, Octyl-2-HG |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H9143 |
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| Price | |
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| Order / More Info | Octyl-Alpha-hydroxyglutarate from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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