| 产品详情 |
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| Product Name | Octyl-Alpha-ketoglutarate |
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| Description | Purity >95%. Hypoxia-inducible factor 1Alpha (HIF-1Alpha) turnover is initiated by prolyl hydroxylases (PHD), which hydroxylate proline residues on HIF-1Alpha, facilitating ubiquitination. PHD activity is linked to the tricarboxylic acid (TCA) cycle, since the intermediate Alpha-ketoglutarate is a PHD substrate and succinate and fumarate inhibit PHD. Mutations in enzymes associated with the TCA cycle occur in certain cancers. Octyl-Alpha-ketoglutarate is a stable, cell-permeable form of Alpha-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle. When used at 1 mM, it stimulates PHD activity, increasing HIF-1Alpha turnover. In addition, octyl-Alpha-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-oxo-pentanedioic acid, 1-octyl ester, Alpha-KG octyl ester |
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| Gene, Accession, CAS # | CAS: 876150-14-0 |
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| Catalog # | LS-H9142 |
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| Price | |
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| Order / More Info | Octyl-Alpha-ketoglutarate from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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