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| Product Name | Tumor Necrosis Factor (TNF) (Active) protein |
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| Description | Recombinant Human TNF Alpha: Tumor Necrosis Factor-alpha (TNF-alpha) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-alpha while cells that express CD8 secrete little or no TNF-alpha. Synthesis of TNF-alpha can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumor activity of TNF-alpha has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-alpha mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF-alpha that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-alpha, which binds to both murine TNF receptors. Based on these results, many TNF-alpha mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF-alpha High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.Alternative Names: Recombinant Human TNF Alpha, Tumor Necrosis Factor, Cachectin, TNF-Alpha, Tumor Necrosis Factor Ligand Superfamily Member 2, TNF-a, TNF, TNFA, TNFSF2 |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF|tnf|dif|tnfa|xtnf|TNF-a|tnfsf2|tnf-alpha|TNF-alpha|DIF|TNFA|TNFSF2|TNFalpha|Tnfa|Tnfsf1a|RATTNF|TNFa|cTNF|TNF-ALPHA|Cachectin|Tnf-alpha|tnfa-like |
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| Gene, Accession, CAS # | Gene ID: 7124 |
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| Catalog # | ABIN1097664 |
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| Order / More Info | Tumor Necrosis Factor (TNF) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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