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| Product Name | Tumor Necrosis Factor (TNF) (Active) protein |
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| Description | TNF is secreted by macrophages, monocytes, neutrophils, T-cells, NK-cells following their stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-alpha while CD8 cells secrete little or no TNF-alpha. The synthesis of TNF-alpha is induced by many different stimuli including interferons, IL2, GM-CSF. The clinical use of the potent anti-tumor activity of TNF-alpha has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-a mutants with low systemic toxicity has been an intense pharmacological interest. Human TNF-a, which binds to the murine TNF-R55 but not to the mouse TNF-R75, exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-a, which binds to both murine TNF receptors. Based on these results, many TNF-a mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro, and exhibited lower systemic toxicity in vivo. Recombinant Human TNF-alpha Variant/Mutant compared with the wild-type, has an amino acid sequence deletion from a.a. 1-7, and the following a.a. substitutes Arg8, Lys9, Arg10 and Phe157 which is proven to have more activity and with less inflammatory side effect in vivo. Recombinant Human TNF-alpha Mutant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 151 amino acids and having a molecular mass of 16,886 Da. Synonym: Tumor Necrosis Factor alpha (TNF)-alpha (mutant), human, TNF-alpha mutant, huma. Formulation: Lyophilized from a 0.2 µm filtered solution in PBS. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TNF|tnf|dif|tnfa|xtnf|TNF-a|tnfsf2|tnf-alpha|TNF-alpha|DIF|TNFA|TNFSF2|TNFalpha|Tnfa|Tnfsf1a|RATTNF|TNFa|cTNF|TNF-ALPHA|Cachectin|Tnf-alpha|tnfa-like |
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| Gene, Accession, CAS # | Gene ID: 7124 |
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| Catalog # | ABIN988259 |
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| Order / More Info | Tumor Necrosis Factor (TNF) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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