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| Product Name | Mithramycin A |
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| Description | Purity >98%. Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression. Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin |
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| Gene, Accession, CAS # | CAS: 18378-89-7 |
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| Catalog # | LS-H4076 |
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| Order / More Info | Mithramycin A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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