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| Product Name | Mithramycin A |
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| Description | Purity >98%. Mithramycin A is a DNA-binding, anti-tumor and neuroprotective antibiotic originally isolated from S. grieseus that has long been used as a chemotherapeutic agent. It mediates its protective function, in part, by regulating acetylation of histones or transcription factors and, thereby, chromatin accessibility to transcriptional machinery. As a selective Sp1 inhibitor, mithramycin A binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, which inhibits their expression. Mithramycin A (at 10-200 nM) can sensitize tumor cells to TRAIL-induced apoptosis and has been used to selectively target tumor cells in many different cancer models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1S)-5-deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1?3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1?3)-2,6-dideoxy-β-D-arabino-hexopyranosyl, A 2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin |
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| Gene, Accession, CAS # | CAS: 18378-89-7 |
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| Catalog # | LS-H8697 |
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| Order / More Info | Mithramycin A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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