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| Product Name | Ingenol-3-angelate |
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| Description | Purity >95%. Ingenol-3-angelate is a hydrophobic diterpene ester that can be isolated from the euphorb E. peplus . It rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption, although it can also initiate apoptosis in some cancer cell lines (LD90 = ~190 µM). Secondarily, ingenol-3-angelate causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity. These actions have relevance in diminishing actinic keratosis and, possibly, other cancers of the skin. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2Z-methyl-2-butenoic acid, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, PEP005, Ingenol mebutate, 3-Ingenyl Angelate, Picato® |
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| Gene, Accession, CAS # | CAS: 75567-37-2 |
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| Catalog # | LS-H8215 |
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| Order / More Info | Ingenol-3-angelate from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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