| 产品详情 |
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| Product Name | Cdk4 Inhibitor |
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| Description | Purity >90%. Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 µM. It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little activity against calcium/calmodulin-dependent protein kinase II and protein kinase A. This compound has been shown to inhibit HCT116 and NCI-H460 tumor cell growth (IC50 s < 3.0 µM) by blocking retinoblastoma protein phosphorylation and inducing G1 cell cycle arrest. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, Cyclin-dependent kinase 4 Inhibitor |
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| Gene, Accession, CAS # | CAS: 546102-60-7 |
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| Catalog # | LS-H7044 |
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| Order / More Info | Cdk4 Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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