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| Product Name | Angiopoietin-1, Recombinant, Human (ANGPT1, ANG-1, KIAA0003) |
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| Description | Purity ≥95% by SDS-PAGE gel and HPLC analyses. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells.Ang-1/ Tie-2 signaling promotes angiogenesis during the development, remodeling, and repair of the vascular system.Transgenic mice lacking expression of either Ang-1 or Tie-2 fail to develop a fully functional cardiovascular system and die before birth.Postnatally, the angiogenic activity of Ang-1/Tie-2 is required during normal tissue repair and remodeling of the female endometrium in the menstrual cycle.Ang-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (Ang-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, Ang-1 enhances endothelial cell survival and capillary morphogenesis, and lessens ca |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143275 |
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| Order / More Info | Angiopoietin-1, Recombinant, Human (ANGPT1, ANG-1, KIAA0003) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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