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| Product Name | Angiostatin, Human |
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| Description | Purity ≥95% by SDS-PAGE. Angiostatin is produced by limited proteolysis of purified human glu-plasminogen using a proprietary enzyme preparation. Angiostatin is a single-chain, proteolytic fragment of glu-plasminogen which has a molecular weight of about 38,000. It is a potent inhibitor of angiogenesis and was first identified and isolated from the serum and urine of tumor bearing mice (1). The mouse protein reportedly extends from threonine-98 through valine-440 (numbering from the NH2-terminus of glu-plasminogen). This fragment of mouse plasminogen, as well as the human equivalent, includes four out of the five kringle domains of plasminogen (1). The inhibition of angiogenesis by angiostatin is directly related to inhibiting the proliferation of endothelial cells (1,2). Because tumor growth is known to be angiogenesis dependent, it was initially hypothesized that the inhibitory properties of angiostatin would have clinical utility in arresting various cancers that are expressed as s |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A2294-05 |
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| Order / More Info | Angiostatin, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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