| 产品详情 |
| Edit |   |
|---|
| Product Name | Angiotensin Converting Enzyme, Bovine (ACE) |
|---|
| Description | Purity ~95% (SDS-PAGE). ACE (kininase II, EC 3.4.15.1) is a zinc dipeptidyl carboxypeptidase (1). ACE catalyses both angiotensin I transformation to angiotensis II (a potent vasopressor agent) and degradation of bradikinin, a vasodepressor. Thus, ACE appears to play a key role in regulating vascular tone and remodeling as well as in the development of atherosclerotic lesions. Increasing evidence asuggests that ACE plays an important role in vascular pathology. Recent studies show two new functions for this important enzyme: 1) ACE enhances presentation of endogenous antigens (such as HIV gp160-derived peptide p18) to MHC class I-restricted T-lymphocytes (1); 2) amino-terminal domain of ACE efficiently cleaves hemoregulatory tetrapeptide N-Ac-Ser-Asp-Lys-Pro (2,3) which is involved in the control of haemopoetic stem cell proliferation (the amount of this peptide greatly decreases in patients undergoing cancer chemotherapy) (4). Specific Activity: ~15mU/ug of protein. Unit Definition: On |
|---|
| Size | 1U |
|---|
| Concentration | n/a |
|---|
| Applications | IP WB |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | A2295-01A |
|---|
| Price | |
|---|
| Order / More Info | Angiotensin Converting Enzyme, Bovine (ACE) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|