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| Product Name | Angiotensin Converting Enzyme, Rat (ACE) |
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| Description | Purity ~95% (SDS-PAGE). ACE (kininase II, EC 3.4.15.1) is a zinc dipeptidyl carboxypeptidase. ACE catalyses both angiotensin I transformation to angiotensis II (a potent vasopressor agent) and degradation of bradikinin, a vaso-depressor. ACE appears to play a key role in regulating vascular tone and remodeling the development of atherosclerotic lesions. Increasing evidence suggests that ACE plays an important role in vascular pathology. Recent studies shows two new functions of this important enzyme: 1) ACE enhances the presentation of endogenous antigens (in particularly HIV 1 gp160-derived peptide p18) to MHC class I-restricted T-lynphocytes (ref. 1); 2) amino-terminal domain of ACE cleaves effectively hemoregulatory tetrapeptide N-Ac-Ser-Asp-Lys-Pro (ref. 2,3) which is involved in the control of hemapoetic stem cell proliferation (the amount of this peptide greatly decreases in patients undergoing cancer chemotherapy) (ref. 4). Activity: ~7mU/ ug of protein (One unit will produce 1u |
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| Size | 1U |
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| Concentration | n/a |
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| Applications | IP WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P47820 |
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| Catalog # | A2295-03 |
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| Price | |
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| Order / More Info | Angiotensin Converting Enzyme, Rat (ACE) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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