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| Product Name | Angiotensin Converting Enzyme 2, Recombinant, Human, Control Peptide (ACE-2, ACEH) |
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| Description | Western Blot Positive Control for A2295-01R (affinity purified antibody). Human ACE-2 (1-740aa, glycosylated secreted protein of MW ~120kD, predicted MW85kD) with His tag was expressed in mouse myeloma cell line NS0 and purified >90% (SDS-PGE). Renin-Angiotensin System (RAS) is a crtical regulator of blood pressure homeostasis. The protease renin cleaves angiotensinogen into inactive decameric peptide angiotensin-I (Ang-I). Angiotensin-converting enzyme (ACE) then cleaves C-terminal dipeptide from Ang-I to form an active octamer angiotensin-II (Ang-II), which can contribute to hypertension by promoting vascular smooth muscle vasocontriction and renal tubule sodium reabsorption. ACE can also cleave many other small peptides including the vasodialating peptide bradykinin into inactive fragment, cleave Alzheimer amyloid beta-peptide (Abeta), retard Abeta aggregation, deposition and fibril formation. ACE mutant mice display spontaneous hypotension, partial male infertility and kidney malfo |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A2295-01J1 |
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| Order / More Info | Angiotensin Converting Enzyme 2, Recombinant, Human, Control Peptide (ACE-2, ACEH) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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