| 产品详情 |
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| Antigenic Specificity | CBF beta |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot: 1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CBF beta Polyclonal Antibody. CBF-beta (Core-binding factor beta), also called polyomavirus enhancer binding protein 2 beta (PEBP2B), belongs to the PEBP2/CBF transcription factor family which regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). CBF-beta is associated with an inversion of chromosome 16 and is associated with acute myeloid leukemia in humans. CBFbeta forms a heterodimer with RUNX1 (runt-related transcription factor 1), which has a DNA binding domain homologous to the pair-rule protein runt in Drosophila melanogaster. Both RUNX1 and CBFbeta are essential for hematopoiesis. Haploinsufficiency of another runt-related protein, RUNX2 (also called CBFA1), causes cleidocranial dysplasia |
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| Immunogen | n/a |
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| Other Names | Core-binding factor subunit beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEBP2-beta, PEA2-beta |
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| Gene, Accession # | Entrez: 865; Uniprot: Q13951 |
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| Catalog # | PA1-317 |
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| Price | |
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| Order / More Info | CBF beta Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 23254331, 23812588, 24522927 |
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