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| Product Name | COMMD1, Recombinant, Human, aa1-190, GST-Tag (COMM Domain-containing Protein 1) |
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| Description | Purity ~90% (SDS-PAGE). Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Protein Murr1 |
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| Gene, Accession, CAS # | SwissProt: Q8N668 |
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| Catalog # | 372833 |
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| Order / More Info | COMMD1, Recombinant, Human, aa1-190, GST-Tag (COMM Domain-containing Protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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