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| Product Name | ICOS IgG2a Fc, Fusion Protein (Inducible Costimulator) (Biotin) |
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| Description | Purified by affinity chromatography. The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Each secondary signal from CD28 or ICOS results in a discrete cytokine secretion profile displayed by the activated T cell. 1 Both activation processes are effectively down regulated by CD152 (CTLA-4) engagement.2 Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be a ligand for ICOS. Functional Application: ICOS-muIg binds to recombinant GL50-muIg in EIA. Human ICOS-muIg/Biotin Fusion Protein* Molecular Structure: A soluble molecule consisting of the extracellular (121aa) domain of mature human ICOS fused to the murine IgG2a Fc (232 aa). Predicted monomeric weight is 42.8kD (amino acid composition only). Transfectant Cell Line: CHO Applications: Suitable for use in Flow Cytometry, ELISA. |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA FC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I0649-80A |
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| Order / More Info | ICOS IgG2a Fc, Fusion Protein (Inducible Costimulator) (Biotin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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