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| Product Name | ICOS IgG2a Fc, Fusion Protein (Inducible Costimulator) (Preservative Free) |
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| Description | Purified by affinity chromatography. The inducible costimulator (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Each secondary signal from CD28 or ICOS results in a discrete cytokine secretion profile displayed by the activated T cell. 1 Both activation processes are effectively down regulated by CD152 (CTLA-4) engagement.2 Human GL50 is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be a ligand for ICOS.3 ICOS-muIg recombinant protein binds to recombinant GL50-muIg in EIA. Functional Application: ICOS-muIg binds to recombinant GL50-muIg in EIA. Human ICOS-muIg Fusion Protein*l Molecular Structure: A soluble molecule consisting of the extracellular (121aa) domain of mature human ICOS fused to the murine IgG2a Fc (232 aa). Transfectant Cell Line: CHO Applications: Suitable for use in Flow Cytometry, ELISA. |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA FC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I0649-80X |
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| Order / More Info | ICOS IgG2a Fc, Fusion Protein (Inducible Costimulator) (Preservative Free) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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