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| Product Name | PHD3, Human, Control Peptide |
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| Description | Oxygen is absolutely critical for the survival of mammalian cells. Hypoxia induced factor (HIF) is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. There are 3-types of alpha subunits (HIF1-3alpha) and one HIF-beta subunits. However, the three HIF-alpha subunits are regulated by oxygen in a similar fashion, i.e. by regulated stabilization of the alpha-subunits. Under normal conditions, HIF-alpha Prolines are hydroxylated at Pro-402 and Pro-564. This allows binding of von Hippel-Lindau (VHL), the substrate recognition component of the E3 ubiquinated ligase complex, subsequent ubiquitination and degradation of HIF-alpha by the proteasome. Under hypoxic conditions, hydroxylation of HIF-alpha is inhibited and this prevents HIF-alpha degradation. The enzymes responsible for HIF-hydroxylation are known as HIF-prolyl hydroxylases (PHD1-3 or HPH1, HPH2, and HPH3). The three PHDs have been identified to hydroxylate the motif, LXXLAP* with *P being the hydroxy |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | PHD3, Human, Control Peptide (PH3, Prolyl Hydroxylase Domain-containing 3, HIF2PH3, HIF-Prolyl hydroxylase 3, EGLN3, egl Nine Homolog 3, SM-20, FLJ21620) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P3375-07A |
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| Price | |
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| Order / More Info | PHD3, Human, Control Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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