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| Product Name | Recombinant Anemonia sulcata Delta-actitoxin-Avd1c |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 6.9kDa. Full Length: 1-47aa. N-terminal 6xHis-tagged. Anemonia sulcata (Mediterranean snakelocks sea anemone). Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC (50)=6.01 nM) and Nav1.2/SCN2A (EC (50)=7.88 nM) (PubMed:15169781). It has also great activity on Nav1.5/SCN5A (EC (50)=49.05 nM), Nav1.4/SCN4A (EC (50)=109.49 nM) and Nav1.6/SCN8A (EC (50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC (50)=759.22 nM) (when measured as the increase in the slow component) (PubMed:15169781). |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | ATX-II |
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| Gene, Accession, CAS # | UniProt: P01528 |
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| Catalog # | RPC25214 |
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| Order / More Info | Recombinant Anemonia sulcata Delta-actitoxin-Avd1c from BIOMATIK |
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| Product Specific References | n/a |
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