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| Product Name | SIK, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). SIK is a protein kinase that is involved in regulating AMPK-related kinases. SIK may mediate the physiological effects of LKB1, including its tumor suppressor function. SIK is also involved in signaling by various proteins like STRAD, NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK that are related to AMPK. Activation of SIK1 by phosphorylation on thr322 can lead to an increase in the catalytic activity of sodium/potassium ATPase alpha subunit at the plasma membrane. This results in an increase in intracellular sodium in intact mammalian cells. Source: Recombinant protein corresponding to human SIK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~61kD Specific Activity: 180nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SIK, Recombinant, Human, GST-Tag (Salt-inducible Kinase 1, Serine/threonine-protein Kinase SIK1, SNF1LK, MSK, SIK1) |
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| Gene, Accession, CAS # | Accession: NM_173354 |
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| Catalog # | 500449 |
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| Order / More Info | SIK, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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