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| Product Name | KIR3DS1, Fc Chimera, Recombinant, Human |
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| Description | Purity ≥ 90% as determined by SDS-PAGE and visualized by silver stain. KIR3DS1 (3DS1, CD158e2) is a type I transmembrane protein that belongs to the killer cell Ig-like receptor (KIR) family. KIRs are expressed on CD56 dim NK cells and T cell subsets where they differentiate normal from abnormal cells, and regulate effector functions in the innate immune system. 1-3 KIRs are named for the number of Ig-like domains (2D or 3D) in the extracellular domain (ECD), and whether they have long or short (L, S) cytoplasmic tails. Like other activating KIRs, KIR3DS1 has a short cytoplasmic tail and a positively charged amino acid (aa) within the transmembrane domain that interacts with the ITAM-bearing signaling adaptor, DAP12. 2, 4 Crosslinking of KIR3DS1 activates cytolysis and induces IFN-γ production, confirming it to be an activating receptor. 4 Approximately 38% of the population expresses KIR3DS1 on the surface of NK cells. 1, 4, 5 Variants lacking the N-terminal Ig-like domain and/o |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | KIR3DS1, Fc Chimera, Recombinant, Human (Killer Cell (Ig)-like Receptor 3DS1, Natural Killer-Associated Transcript 10, NKAT-10) |
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| Gene, Accession, CAS # | SwissProt: Q14943 |
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| Catalog # | K1862-38 |
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| Order / More Info | KIR3DS1, Fc Chimera, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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