| 产品详情 |
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| Product Name | PI-103 |
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| Description | Purity >98%. The phosphatidylinositol 3-kinases (PI3K) family of enzymes is comprised of 15 members that are divided into 3 classes according to their structure, substrate specificity, and mode of regulation. PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110Alpha), and mTOR. The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110Alpha, mTORC1, PI3-KC2Beta, p110Delta, mTORC2, p110Beta, and p110Gamma, respectively. PI-103 exhibits antiproliferative activity against a panel of glioma cell lines in vitro at a concentration of 0.5 µM. It also inhibits growth of established human glioma tumor xenografts in vivo with no observable toxicity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-phenol |
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| Gene, Accession, CAS # | CAS: 371935-74-9 |
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| Catalog # | LS-H9400 |
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| Price | |
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| Order / More Info | PI-103 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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